Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11095324 | 0.94 | NPC1 (0.36) | CYP19A1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL1332286 | 0.94 | NPC1 (0.36) | CYP19A1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL6551912 | 0.81 | HSD17B10 (0.39) | CYP19A1NPC1 | |
| SCHEMBL977159 | 0.80 | MAP3K14 (0.38) | CYP19A1NPC1LMNADDB1CRBN | |
| SCHEMBL3805680 | 0.78 | MAP3K14 (0.36) | NPC1LMNADDB1CRBNMAP3K14 | |
| SCHEMBL7530544 | 0.78 | MAP3K14 (0.39) | CYP19A1LMNADDB1CRBNMAP3K14 | |
| SCHEMBL2099423 | 0.77 | PRKCA (0.47) | CYP19A1NPC1 | |
| SCHEMBL1273192 | 0.77 | MAP3K14 (0.35) | LMNADDB1CRBNMAP3K14 | |
| SCHEMBL9468465 | 0.77 | MAP3K14 (0.35) | CYP19A1LMNADDB1CRBNMAP3K14 | |
| SCHEMBL10488014 | 0.77 | MAP3K14 (0.35) | LMNADDB1CRBNMAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049860-B1 | PROCESS FOR THE PREPARATION OF REACTIVE THYROID GLAND HORMONES T3 AND T4 DERIVATIVES THAT ARE CAPABLE OF COUPLING, AND THEIR USE | Roche Diagnostics GmbH (DE) | 1984-10-03 | — | — | EP | disclosed |
| EP-0049860-A1 | Process for the preparation of reactive thyroid gland hormones T3 and T4 derivatives that are capable of coupling, and their use | Roche Diagnostics GmbH (DE) | 1982-04-21 | — | — | EP | disclosed |