Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11067006 | 0.97 | SLC6A4 (0.44) | SLC6A3SLC6A4SLC6A2HSD11B1OPRM1 | |
| Ethylene SCHEMBL11095151 | 0.83 | MEN1 (0.53) | OPRM1OPRL1OPRK1KMT2AMEN1 | |
| SCHEMBL2793612 | 0.82 | OPRM1 (0.48) | SLC6A3SLC6A4SLC6A2OPRM1OPRL1 | |
| SCHEMBL11097091 | 0.81 | SLC6A4 (0.39) | SLC6A3SLC6A4HSD11B1OPRM1OPRL1 | |
| Ethylene SCHEMBL11096239 | 0.81 | OPRM1 (0.39) | SLC6A3SLC6A4HSD11B1OPRM1OPRL1 | |
| Hydrochloric Acid SCHEMBL28043928 | 0.80 | OPRM1 (0.47) | SLC6A3SLC6A4SLC6A2OPRM1OPRL1 | |
| SCHEMBL11092884 | 0.79 | SLC6A4 (0.40) | SLC6A3SLC6A4SLC6A2HSD11B1OPRM1 | |
| SCHEMBL11091107 | 0.79 | HSD11B1 (0.41) | SLC6A3SLC6A4HSD11B1OPRM1OPRL1 | |
| SCHEMBL735724 | 0.79 | MEN1 (0.57) | OPRM1OPRL1OPRK1KMT2AMEN1 | |
| SCHEMBL11097553 | 0.79 | SLC6A4 (0.62) | SLC6A3SLC6A4SLC6A2HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |