Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA4 | P22748 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL11098345 | 0.86 | ALDH1A1 (0.49) | ALDH1A1TSHRLMNAPKMMAPK1 | |
| Potassium Ion SCHEMBL11123155 | 0.85 | ALDH1A1 (0.48) | ALDH1A1TSHRLMNAPKMMAPK1 | |
| Potassium Ion SCHEMBL11224520 | 0.82 | ALDH1A1 (0.46) | ALDH1A1TSHRLMNAPKMMAPK1 | |
| Sulosemide SCHEMBL10965264 | 0.81 | ALDH1A1 (0.48) | ALDH1A1TSHRLMNAPKMMAPK1 | |
| Potassium Ion SCHEMBL11102432 | 0.81 | ALDH1A1 (0.45) | ALDH1A1TSHRLMNAPKMMAPK1 | |
| Potassium Ion SCHEMBL11228455 | 0.81 | ALDH1A1 (0.48) | ALDH1A1TSHRLMNAPKMMAPK1 | |
| SCHEMBL11230883 | 0.81 | ALDH1A1 (0.49) | ALDH1A1TSHRLMNAPKMMAPK1 | |
| Potassium Ion SCHEMBL11103412 | 0.81 | ALDH1A1 (0.45) | ALDH1A1TSHRLMNAPKMMAPK1 | |
| Potassium Ion SCHEMBL11101257 | 0.80 | ALDH1A1 (0.44) | ALDH1A1TSHRLMNAPKMMAPK1 | |
| Potassium Ion SCHEMBL11100066 | 0.80 | ALDH1A1 (0.44) | ALDH1A1TSHRLMNAPKMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034746-B1 | 5-SULFAMOYL-ORTHANILIC ACIDS, PROCESSES FOR THEIR PREPARATION, THERAPEUTIC COMPOSITIONS CONTAINING THEM AND THE COMPOUNDS FOR USE IN THERAPY | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-01-18 | — | — | EP | disclosed |
| US-4339446-A | 5-Sulfamoyl-orthanilic acids, processes for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-07-13 | — | — | US | disclosed |