Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 6/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2440151 | 0.83 | OPRL1 (0.52) | OPRK1OPRM1 | |
| SCHEMBL11074012 | 0.80 | OPRM1 (0.43) | OPRK1OPRM1OPRD1SIGMAR1SLC6A2 | |
| Ethylene SCHEMBL10832290 | 0.77 | OPRD1 (0.41) | OPRK1OPRM1OPRD1SIGMAR1SLC6A2 | |
| Cyclopropane SCHEMBL11098599 | 0.77 | OPRM1 (0.42) | OPRK1OPRM1OPRD1SIGMAR1SLC6A2 | |
| SCHEMBL11069932 | 0.76 | OPRL1 (0.41) | OPRK1OPRM1SLC6A2SLC6A4MEN1 | |
| SCHEMBL11070605 | 0.74 | MAOA (0.38) | OPRK1OPRM1SLC6A2SLC6A4KMT2A | |
| SCHEMBL11090331 | 0.74 | MAOA (0.38) | OPRK1OPRM1SLC6A2SLC6A4KMT2A | |
| SCHEMBL11096526 | 0.74 | MAOA (0.38) | OPRK1OPRM1SLC6A2SLC6A4KMT2A | |
| SCHEMBL11557913 | 0.74 | OPRM1 (0.43) | OPRK1OPRM1OPRD1SIGMAR1SLC6A2 | |
| SCHEMBL11092002 | 0.73 | OPRM1 (0.44) | OPRK1OPRM1OPRD1SIGMAR1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |