Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | PDE6D | O43924 | 1/20 | 0.44 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.44 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11160756 | 0.93 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LMNARAB9ARECQL | |
| SCHEMBL6202033 | 0.89 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2LMNARAB9ARECQL | |
| SCHEMBL11162148 | 0.85 | LMNA (0.49) | ALDH1A1SMN1; SMN2LMNAHPGDMAPT | |
| SCHEMBL11098803 | 0.81 | IDO1 (0.43) | ALDH1A1SMN1; SMN2LMNARAB9ARECQL | |
| SCHEMBL11093772 | 0.81 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2LMNARAB9ARECQL | |
| SCHEMBL11163273 | 0.81 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2LMNARAB9ARECQL | |
| SCHEMBL7609835 | 0.80 | GP6 (0.42) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL11095083 | 0.80 | TP53 (0.55) | ALDH1A1SMN1; SMN2LMNARAB9ARECQL | |
| SCHEMBL5330186 | 0.80 | AR (0.51) | ALDH1A1LMNARAB9AHPGDMAPT | |
| SCHEMBL6229258 | 0.79 | PTGDR2 (0.39) | ALDH1A1SMN1; SMN2LMNARAB9ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028834-B1 | IMIDAZOLE-5-ACETIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1984-01-18 | — | — | EP | disclosed |
| US-4355040-A | Hypotensive imidazole-5-acetic acid derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-10-19 | — | — | US | disclosed |
| EP-0028834-A1 | Imidazole-5-acetic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1981-05-20 | — | — | EP | disclosed |