Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2580796 | 0.89 | IGF1R (0.53) | CALM1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14283892 | 0.85 | LTA4H (0.53) | CALM1ALOX15IGF1RESR1CYP19A1 | |
| SCHEMBL8430733 | 0.85 | KEAP1 (0.59) | ALDH1A1CYP3A4HPGDMEN1KMT2A | |
| SCHEMBL2579101 | 0.85 | AMY1A (0.54) | CALM1NPC1RAB9AALOX15IGF1R | |
| SCHEMBL7283988 | 0.85 | CALM1 (0.50) | CALM1ALDH1A1CYP3A4HPGDMEN1 | |
| SCHEMBL10820384 | 0.83 | CALM1 (0.49) | CALM1ALDH1A1CYP3A4HPGDMEN1 | |
| SCHEMBL2576239 | 0.83 | IGF1R (0.47) | CALM1NPC1RAB9ASMN1; SMN2ALOX15 | |
| SCHEMBL227700 | 0.82 | ESR1 (0.61) | CALM1MEN1KMT2AALOX15IGF1R | |
| SCHEMBL9188763 | 0.80 | AMY1A (0.52) | ALDH1A1CYP3A4HPGDMEN1KMT2A | |
| SCHEMBL6201748 | 0.80 | NPC1 (0.49) | MEN1NPC1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0032063-B1 | NOVEL SUBSTITUTED ARYLENE COMPOUNDS AND PROCESSES FOR THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1984-03-14 | — | — | EP | disclosed |
| US-4351950-A | Anti-arteriosclerotic agents | WARNER-LAMBERT COMPANY (US) | 1982-09-28 | — | — | US | disclosed |
| EP-0032063-A2 | Novel substituted arylene compounds and processes for their production | WARNER-LAMBERT COMPANY (US) | 1981-07-15 | — | — | EP | disclosed |