Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.56 |
| ▸ | CTSS | P25774 | 2/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11026849 | 0.89 | CHRM1 (0.57) | HTR1AADRA2ADRD2HTR2ASLC6A4 | |
| SCHEMBL11096897 | 0.88 | HTR1A (0.56) | HTR1AADRA2ADRD2HTR2ASLC6A4 | |
| SCHEMBL11027738 | 0.87 | HTR1A (0.60) | HTR1AADRA2ADRD2HTR2ASLC6A4 | |
| SCHEMBL11096796 | 0.87 | DRD2 (0.61) | HTR1ADRD2HTR2ACHRM1OPRM1 | |
| SCHEMBL11096564 | 0.86 | DRD2 (0.48) | HTR1AADRA2ADRD2HTR2ASLC6A4 | |
| SCHEMBL11025222 | 0.85 | HTR1A (0.59) | HTR1AADRA2ADRD2HTR2ASLC6A4 | |
| SCHEMBL11024904 | 0.85 | HTR1A (0.57) | HTR1AADRA2ADRD2HTR2ASLC6A4 | |
| SCHEMBL11040218 | 0.85 | HTR1A (0.57) | HTR1AADRA2ADRD2HTR2ASLC6A4 | |
| SCHEMBL11093124 | 0.85 | OPRM1 (0.58) | HTR1AADRA2ADRD2HTR2ASLC6A4 | |
| Axamozide SCHEMBL11022863 | 0.84 | OPRM1 (0.60) | HTR1AADRA2ADRD2HTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4470989-A | Neuroleptic n-oxacyclyl-alkylpiperidine derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-09-11 | — | — | US | disclosed |
| EP-0068261-A1 | N-oxacyclyl-alkylpiperidine derivatives, their preparation, pharmaceutical preparations containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-01-05 | — | — | EP | disclosed |