Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11088920 | 0.87 | CYP3A4 (0.39) | ACHEOPRM1OPRL1ALOX5CYP3A4 | |
| SCHEMBL11075750 | 0.85 | OPRM1 (0.46) | ACHEOPRM1OPRL1ALOX5SMN1; SMN2 | |
| SCHEMBL11097716 | 0.84 | OPRM1 (0.43) | ACHEOPRM1OPRL1SMN1; SMN2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11099770 | 0.84 | OPRM1 (0.45) | ACHEOPRM1OPRL1ALOX5SMN1; SMN2 | |
| SCHEMBL11070774 | 0.83 | CYP3A4 (0.45) | ACHEOPRM1OPRL1ALOX5CYP3A4 | |
| SCHEMBL11095163 | 0.82 | OPRK1 (0.45) | OPRM1OPRL1 | |
| SCHEMBL11092425 | 0.82 | CYP3A4 (0.38) | ACHEOPRM1OPRL1ALOX5CYP3A4 | |
| SCHEMBL11099341 | 0.78 | ACHE (0.39) | ACHEOPRM1OPRL1CYP3A4LMNA | |
| SCHEMBL11093289 | 0.77 | ALDH1A1 (0.41) | ACHEOPRM1SMN1; SMN2CYP3A4LMNA | |
| SCHEMBL11077394 | 0.77 | OPRM1 (0.45) | OPRM1OPRL1SMN1; SMN2CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |