Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.45 |
| ▸ | PTAFR | P25105 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11035720 | 0.99 | DRD2 (0.47) | DRD2HTR2AHTR2CHTR2BDRD4 | |
| SCHEMBL11036336 | 0.92 | SETD7 (0.53) | DRD2HTR2AHTR2CHTR2BDRD4 | |
| SCHEMBL11033270 | 0.89 | SLC6A9 (0.49) | DRD2HTR2AHTR2CHTR2BDRD4 | |
| SCHEMBL11097971 | 0.82 | OPRD1 (0.51) | DRD2HTR2AHTR2CHTR2BDRD4 | |
| Hydrochloric Acid SCHEMBL11036480 | 0.81 | OPRD1 (0.50) | DRD2HTR2AHTR2CHTR2BDRD4 | |
| SCHEMBL11034679 | 0.80 | OPRK1 (0.49) | DRD2HTR2AHTR2CHTR2BDRD4 | |
| SCHEMBL4257154 | 0.79 | SETD7 (0.56) | DRD2HTR2AHTR2CHTR2BDRD4 | |
| SCHEMBL8316876 | 0.77 | OPRD1 (0.53) | DRD2HTR2AHTR2CHTR2BDRD4 | |
| Hydrochloric Acid SCHEMBL11034935 | 0.75 | HRH1 (0.59) | DRD2HTR2AHTR2CHTR2BOPRD1 | |
| SCHEMBL11037025 | 0.74 | HRH1 (0.56) | DRD2HTR2AHTR2CHTR2BDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0048705-B1 | 2-(4-(DIPHENYLMETHYLENE)-1-PIPERIDINYL)-ACETIC ACIDS AND THEIR AMIDES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | U C B, S.A. (BE) | 1984-07-11 | — | — | EP | disclosed |
| EP-0048705-A1 | 2-(4-(Diphenylmethylene)-1-piperidinyl)-acetic acids and their amides, their preparation and pharmaceutical preparations containing them | U C B, S.A. (BE) | 1982-03-31 | — | — | EP | disclosed |