Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | PTAFR | P25105 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.46 |
| ▸ | TUBB | P07437 | 5/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.46 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.46 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13414990 | 0.92 | ACHE (0.54) | ACHEPTPN1PTAFRMEN1KMT2A | |
| SCHEMBL8885280 | 0.88 | ACHE (0.46) | ACHEPTPN1PTAFRMEN1KMT2A | |
| SCHEMBL8886456 | 0.84 | FPR2 (0.45) | ACHEPTPN1PTAFRMEN1KMT2A | |
| SCHEMBL8886677 | 0.84 | ACHE (0.43) | ACHEPTPN1PTAFRMEN1KMT2A | |
| SCHEMBL5783392 | 0.82 | PTPN1 (0.40) | ACHEPTPN1PTAFRMEN1KMT2A | |
| SCHEMBL7814590 | 0.81 | ACHE (0.44) | ACHEPTPN1PTAFRMEN1KMT2A | |
| SCHEMBL4178653 | 0.80 | ACHE (0.40) | ACHEPTPN1PTAFRMEN1KMT2A | |
| SCHEMBL18288113 | 0.78 | ALDH1A1 (0.58) | ACHEPTAFRMAPK3MAPK1ALDH1A1 | |
| SCHEMBL5785856 | 0.78 | PTPN1 (0.39) | ACHEPTPN1PTAFRMEN1KMT2A | |
| SCHEMBL6822928 | 0.78 | PTAFR (0.69) | ACHEPTPN1PTAFRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0046307-B1 | NOVEL URACIL DERIVATIVES, PROCESS FOR PREPARING THE SAME AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Chugai Seiyaku Kabushiki Kaisha (JP) | 1984-11-21 | — | — | EP | disclosed |
| US-4415573-A | ANTITUMOR AND ANTICARCINOGENIC AGENTS; REACTING A 1,3-DIOXOLANE AND A URACIL USING AN ACID CATALYST AND SOLVENT | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1983-11-15 | — | — | US | disclosed |
| EP-0046307-A1 | Novel uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1982-02-24 | — | — | EP | disclosed |