Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | HTR2C | P28335 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.53 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11100352 | 0.89 | DRD2 (0.47) | DRD2HTR2CHTR1AHTR2AHTR2B | |
| SCHEMBL11101393 | 0.89 | DRD2 (0.59) | DRD2HTR2CHTR1AHTR2AHTR2B | |
| SCHEMBL11096897 | 0.89 | HTR1A (0.56) | DRD2HTR1AHTR2AOPRM1CHRM1 | |
| SCHEMBL11095945 | 0.88 | DRD2 (0.62) | DRD2HTR2CHTR1AHTR2AHTR2B | |
| SCHEMBL11101398 | 0.88 | DRD2 (0.62) | DRD2HTR2CHTR1AHTR2AHTR2B | |
| SCHEMBL11096050 | 0.87 | DRD2 (0.62) | DRD2HTR2CHTR1AHTR2AHTR2B | |
| SCHEMBL11096796 | 0.86 | DRD2 (0.61) | DRD2HTR2CHTR1AHTR2AHTR2B | |
| SCHEMBL9943304 | 0.85 | DRD2 (0.61) | DRD2HTR2CHTR1AHTR2AHTR2B | |
| SCHEMBL11098879 | 0.84 | OPRM1 (0.58) | DRD2HTR2CHTR1AHTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL11096032 | 0.84 | DRD2 (0.61) | DRD2HTR2CHTR1AHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4470989-A | Neuroleptic n-oxacyclyl-alkylpiperidine derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-09-11 | — | — | US | disclosed |
| EP-0068261-A1 | N-oxacyclyl-alkylpiperidine derivatives, their preparation, pharmaceutical preparations containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-01-05 | — | — | EP | disclosed |