Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11289896 | 0.88 | KDM4E (0.46) | KDM4EALDH1A1ADRB2ADRB1HTR1A | |
| SCHEMBL11287858 | 0.88 | KDM4E (0.46) | KDM4EALDH1A1ADRB2ADRB1HTR1A | |
| SCHEMBL11104667 | 0.88 | KDM4E (0.46) | KDM4EALDH1A1ADRB2ADRB1HTR1A | |
| SCHEMBL11108141 | 0.85 | L3MBTL1 (0.47) | KDM4EALDH1A1HTR1ALMNASLC6A2 | |
| SCHEMBL11100661 | 0.83 | PPARD (0.41) | KDM4EALDH1A1HTR1ALMNAADRA2C | |
| SCHEMBL11109252 | 0.81 | DRD2 (0.47) | KDM4EALDH1A1LMNACYP1A2CYP2D6 | |
| SCHEMBL11104158 | 0.81 | KDM4E (0.45) | KDM4EALDH1A1ADRB2ADRB1HTR1A | |
| SCHEMBL11102123 | 0.79 | MEN1 (0.47) | ALDH1A1CYP1A2CYP2D6TDP1BRD4 | |
| SCHEMBL11106513 | 0.77 | LMNA (0.45) | KDM4EALDH1A1LMNASLC6A2SLC6A4 | |
| SCHEMBL11103526 | 0.77 | ALDH1A1 (0.49) | KDM4EALDH1A1LMNACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4435402-A | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them | SANKYO COMPANY, LIMITED (JP) | 1984-03-06 | — | — | US | disclosed |
| EP-0057440-A1 | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them | SANKYO COMPANY LIMITED (JP) | 1982-08-11 | — | — | EP | disclosed |