SCHEMBL11110277

SCHEMBL11110277

COP(=O)(OC)Sc1nc(Cl)c(Cl)cc1Cl

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
ALDH1A1 P00352 2/20 0.33
CYP3A4 P08684 2/20 0.33
TSHR P16473 2/20 0.33
MAPT P10636 1/20 0.33
ALOX15 P16050 1/20 0.33
ALOX12 P18054 1/20 0.33
MAPK1 P28482 1/20 0.33
ATM Q13315 1/20 0.33
HSD17B10 Q99714 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
HIF1A Q16665 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11110306 0.82 TDP1 (0.47) TDP1MEN1KMT2AALDH1A1CYP3A4
SCHEMBL3638775 0.80 TDP1 (0.47) TDP1MEN1KMT2AALDH1A1CYP3A4
SCHEMBL27542334 0.77 MMP1 (0.37) TDP1MEN1KMT2A
SCHEMBL8755038 0.72 ALDH1A1 (0.39) TDP1MEN1KMT2AALDH1A1CYP3A4
SCHEMBL6575560 0.69 MMP1 (0.34) TDP1MEN1KMT2AALDH1A1CYP3A4
Fospirate SCHEMBL6736860 0.67 TDP1 (0.65) TDP1MEN1KMT2AALDH1A1CYP3A4
Fospirate SCHEMBL30538657 0.67 TDP1 (0.65) TDP1MEN1KMT2AALDH1A1CYP3A4
Fospirate SCHEMBL117867 0.67 TDP1 (0.65) TDP1MEN1KMT2AALDH1A1CYP3A4
SCHEMBL2366051 0.62 TDP1 (0.41) TDP1MEN1KMT2AALDH1A1CYP3A4
SCHEMBL31254099 0.61 TDP1 (0.58) TDP1MEN1KMT2AALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0017738-B1 AN INSECTICIDAL AND MITICIDAL COMPOSITION WHICH CONTAINS A CARBAMATE AND AN ORGANIC PHOSPHORUS COMPOUND, AND A METHOD OF CONTROLLING INSECTS AND MITES THEREWITH IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-08-08 EP claimed
EP-0017738-B1 AN INSECTICIDAL AND MITICIDAL COMPOSITION WHICH CONTAINS A CARBAMATE AND AN ORGANIC PHOSPHORUS COMPOUND, AND A METHOD OF CONTROLLING INSECTS AND MITES THEREWITH IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-08-08 EP disclosed
EP-0017738-A1 An insecticidal and miticidal composition which contains a carbamate and an organic phosphorus compound, and a method of controlling insects and mites therewith IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1980-10-29 EP disclosed