Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 9/20 | 0.46 |
| ▸ | IDH2 | P48735 | 2/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | PGK2 | P07205 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30818068 | 1.00 | IDH1 (0.46) | IDH1IDH2P2RX7ADRB1NOTUM | |
| Hydrochloric Acid SCHEMBL30818101 | 0.98 | IDH1 (0.45) | IDH1IDH2P2RX7ADRB1NOTUM | |
| Hydrochloric Acid SCHEMBL1192288 | 0.98 | IDH1 (0.45) | IDH1IDH2P2RX7ADRB1NOTUM | |
| SCHEMBL1273797 | 0.89 | IRAK4 (0.37) | IDH1IDH2P2RX7ADRB1PGK1 | |
| SCHEMBL3295150 | 0.83 | P2RX7 (0.50) | IDH1IDH2P2RX7ADRB1NOTUM | |
| SCHEMBL2609323 | 0.82 | IDH1 (0.49) | IDH1IDH2P2RX7ADRB1NOTUM | |
| SCHEMBL1192408 | 0.80 | ALDH1A1 (0.46) | P2RX7 | |
| SCHEMBL29168104 | 0.78 | IRAK4 (0.33) | IDH1IDH2P2RX7PGK1PGK2 | |
| SCHEMBL1111306 | 0.78 | ADRB1 (0.46) | IDH1IDH2P2RX7ADRB1NOTUM | |
| SCHEMBL30818115 | 0.78 | ADRB1 (0.46) | IDH1IDH2P2RX7ADRB1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117529476-A | Preparation of substituted 1, 2-diamino heterocyclic derivatives and their use as medicaments | 亚飞络思制药公司 | 2024-02-06 | — | — | CN | disclosed |
| US-8426448-B2 | 1,5-diphenyl-pyrrolidin-2-one compounds as CB-1 ligands | ELI LILLY AND COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| US-8426448-B2 | 1,5-diphenyl-pyrrolidin-2-one compounds as CB-1 ligands | ELI LILLY AND COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| US-8426448-B2 | 1,5-diphenyl-pyrrolidin-2-one compounds as CB-1 ligands | ELI LILLY AND COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| US-20110028520-A1 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2011-02-03 | — | — | US | disclosed |
| US-20110028520-A1 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2011-02-03 | — | — | US | disclosed |
| US-20110028520-A1 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2011-02-03 | — | — | US | disclosed |
| EP-2278968-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009131814-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009131814-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028520-A1 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | CNR1, CNR2, GPR119 | IDH1 4405/4885IDH2 4194/4885P2RX7 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.