Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | DBH | P09172 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11116210 | 0.89 | PTPN1 (0.44) | PTPN1ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL6433515 | 0.78 | ESR2 (0.44) | MAOAMAOB | |
| SCHEMBL728537 | 0.73 | PTPN1 (0.46) | PTPN1ALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL731336 | 0.72 | NPC1 (0.50) | ALDH1A1HPGDMAPTMAOALMNA | |
| SCHEMBL6763544 | 0.69 | PTPN1 (0.41) | PTPN1ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL28347434 | 0.69 | ALDH1A1 (0.50) | PTPN1ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL6436211 | 0.68 | MAOA (0.47) | MAOAMAOB | |
| SCHEMBL17910097 | 0.67 | G6PD (0.46) | ALDH1A1HPGDHSD17B10MAPTMCL1 | |
| Ethylene SCHEMBL7112141 | 0.67 | ALDH1A1 (0.60) | PTPN1ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL22569106 | 0.67 | PTGS2 (0.40) | PTPN1ALDH1A1HPGDHSD17B10BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0037062-B1 | SUBSTITUTED 3-ARYL-2-CYCLOALKENE-1-ONES, PROCESS FOR THEIR PREPARATION AND THEIR PARMACEUTICAL USE | Beiersdorf Aktiengesellschaft (DE) | 1984-10-17 | — | — | EP | disclosed |
| US-4401831-A | ADRENOLYTIC AND HYPOTENSIVE AGENTS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1983-08-30 | — | — | US | disclosed |
| US-4358460-A | HYPOTENSIVE, ANTIARRHYTHMIA, ANGINA PECTORIS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1982-11-09 | — | — | US | disclosed |
| EP-0037062-A2 | Substituted 3-aryl-2-cycloalkene-1-ones, process for their preparation and their parmaceutical use | Beiersdorf Aktiengesellschaft (DE) | 1981-10-07 | — | — | EP | disclosed |