Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2527732 | 0.80 | ALDH1A1 (0.53) | ALDH1A1HTTSMN1; SMN2LMNAHPGD | |
| SCHEMBL6552462 | 0.80 | LMNA (0.61) | ALDH1A1HTTSMN1; SMN2LMNAPKM | |
| SCHEMBL8605585 | 0.77 | ALDH1A1 (0.53) | ALDH1A1HTTSMN1; SMN2LMNAHPGD | |
| SCHEMBL11142367 | 0.77 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2HPGDAKR1C3NPC1 | |
| SCHEMBL17946119 | 0.77 | ALDH1A1 (0.60) | ALDH1A1HTTSMN1; SMN2LMNAPKM | |
| SCHEMBL9375911 | 0.75 | MMP13 (0.43) | ALDH1A1LMNANPC1RAB9ACA12 | |
| SCHEMBL5569349 | 0.75 | SMN1; SMN2 (0.55) | ALDH1A1HTTSMN1; SMN2LMNANPC1 | |
| SCHEMBL1776266 | 0.75 | KDM1A (0.59) | ALDH1A1HTTSMN1; SMN2LMNAPKM | |
| SCHEMBL22144464 | 0.75 | PARP15 (0.48) | ALDH1A1HTTSMN1; SMN2LMNAPKM | |
| SCHEMBL29930365 | 0.74 | TP53 (0.59) | ALDH1A1HTTSMN1; SMN2LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0106988-A1 | Pharmacologically active lactam derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-05-02 | — | — | EP | claimed |
| EP-0106988-A1 | Pharmacologically active lactam derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-05-02 | — | — | EP | disclosed |