Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 8/20 | 0.39 |
| ▸ | HTR2C | P28335 | 8/20 | 0.39 |
| ▸ | HRH1 | P35367 | 6/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.39 |
| ▸ | DRD1 | P21728 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11113110 | 0.93 | HTR2B (0.44) | HTR2BHTR2AHTR2CHRH1ADRA2A | |
| SCHEMBL11114001 | 0.89 | MEN1 (0.40) | HTR2BHTR2AHTR2CHRH1DRD2 | |
| SCHEMBL11155482 | 0.87 | HTR2A (0.40) | HTR2AHTR2CHRH1KMT2ASLC6A3 | |
| SCHEMBL11115157 | 0.86 | HTR2B (0.43) | HTR2BHTR2AHTR2CHRH1ADRA2A | |
| SCHEMBL11115014 | 0.85 | TBXAS1 (0.40) | HTR2AHTR2CHRH1SLC6A3TBXAS1 | |
| SCHEMBL11117014 | 0.84 | TBXAS1 (0.38) | HTR2BHTR2AHTR2CHRH1ADRA2A | |
| SCHEMBL11113353 | 0.80 | HRH1 (0.41) | HTR2BHTR2AHTR2CHRH1ADRA2A | |
| SCHEMBL11117688 | 0.79 | HTR2B (0.44) | HTR2BHTR2AHTR2CHRH1ADRA2A | |
| SCHEMBL11116048 | 0.78 | TBXAS1 (0.41) | HTR2AHTR2CHRH1TBXA2RKDM4E | |
| SCHEMBL11111420 | 0.76 | ALOX15 (0.40) | HTR2BHTR2AHTR2CHRH1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0038564-B1 | DIBENZ (B,E) OXEPIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-09-12 | — | — | EP | disclosed |
| US-4396550-A | ANTICHOLINERGIC, ANTIHISTIMINIC AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-08-02 | — | — | US | disclosed |
| EP-0038564-A1 | Dibenz (b,e) oxepin derivatives and pharmaceutical compositions comprising them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1981-10-28 | — | — | EP | disclosed |