Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11115014 | 0.93 | TBXAS1 (0.40) | TBXAS1HRH1HTR2AHTR2CSMPD1 | |
| SCHEMBL11113224 | 0.90 | TBXAS1 (0.40) | TBXAS1HRH1HTR2AHTR2CALDH1A1 | |
| SCHEMBL11113353 | 0.86 | HRH1 (0.41) | TBXAS1HRH1HTR2AHTR2CKDM4E | |
| SCHEMBL11113367 | 0.85 | ALDH1A1 (0.39) | TBXAS1HRH1HTR2AHTR2CKDM4E | |
| SCHEMBL11113110 | 0.85 | HTR2B (0.44) | TBXAS1HRH1HTR2AHTR2CKDM4E | |
| SCHEMBL11117688 | 0.85 | HTR2B (0.44) | TBXAS1HRH1HTR2AHTR2CKDM4E | |
| SCHEMBL11001965 | 0.81 | TBXAS1 (0.46) | TBXAS1GAATBXA2R | |
| SCHEMBL11113259 | 0.80 | TRPC5 (0.40) | TBXAS1KDM4EALDH1A1 | |
| SCHEMBL10911835 | 0.80 | TBXAS1 (0.49) | TBXAS1HTR2CKDM4EALDH1A1GAA | |
| SCHEMBL10877858 | 0.79 | TBXA2R (0.52) | TBXAS1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0038564-B1 | DIBENZ (B,E) OXEPIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-09-12 | — | — | EP | claimed |
| US-4396550-A | ANTICHOLINERGIC, ANTIHISTIMINIC AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-08-02 | — | — | US | claimed |
| EP-0038564-B1 | DIBENZ (B,E) OXEPIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-09-12 | — | — | EP | disclosed |
| US-4396550-A | ANTICHOLINERGIC, ANTIHISTIMINIC AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-08-02 | — | — | US | disclosed |
| EP-0038564-A1 | Dibenz (b,e) oxepin derivatives and pharmaceutical compositions comprising them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1981-10-28 | — | — | EP | disclosed |