Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 6/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.37 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11118942 | 0.76 | DRD2 (0.41) | GRM7SLC6A2SLC6A4TBXAS1DRD2 | |
| SCHEMBL10559305 | 0.75 | DRD2 (0.42) | GRM7SLC6A2SLC6A4MAPK14DRD2 | |
| SCHEMBL10447051 | 0.74 | SLC6A2 (0.39) | GRM7SLC6A2SLC6A4MAPK14DRD2 | |
| SCHEMBL10444467 | 0.73 | GRM7 (0.40) | GRM7SLC6A2SLC6A4MAPK14DRD2 | |
| SCHEMBL11112671 | 0.72 | TBXAS1 (0.41) | GRM7SLC6A2SLC6A4TBXAS1SLC6A3 | |
| SCHEMBL11117688 | 0.72 | HTR2B (0.44) | SLC6A2SLC6A4TBXAS1MAPK14DRD2 | |
| SCHEMBL11118052 | 0.72 | ACHE (0.39) | SLC6A2SLC6A4CHRM1P4HBDRD2 | |
| SCHEMBL7526493 | 0.70 | DRD2 (0.39) | GRM7SLC6A2SLC6A4MAPK14DRD2 | |
| SCHEMBL11115157 | 0.70 | HTR2B (0.43) | SLC6A2SLC6A4TBXAS1DRD2DRD3 | |
| SCHEMBL11129673 | 0.70 | TBXAS1 (0.38) | SLC6A2SLC6A4TBXAS1MAPK14DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0038564-B1 | DIBENZ (B,E) OXEPIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-09-12 | — | — | EP | disclosed |
| US-4396550-A | ANTICHOLINERGIC, ANTIHISTIMINIC AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-08-02 | — | — | US | disclosed |
| EP-0038564-A1 | Dibenz (b,e) oxepin derivatives and pharmaceutical compositions comprising them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1981-10-28 | — | — | EP | disclosed |