Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
| ▸ | PPIG | Q13427 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9821188 | 0.80 | TP53 (0.67) | TP53LMNASMN1; SMN2KDM4EHTT | |
| SCHEMBL11112655 | 0.80 | TP53 (0.47) | TP53LMNASMN1; SMN2TSHRMTNR1A | |
| SCHEMBL11107180 | 0.73 | APEX1 (0.65) | TP53LMNATSHROPRM1OPRL1 | |
| SCHEMBL9628959 | 0.70 | APEX1 (0.69) | TP53LMNASMN1; SMN2TSHROPRM1 | |
| SCHEMBL564041 | 0.68 | DRD2 (0.41) | LMNAMAPTMTNR1AKMT2A | |
| SCHEMBL1906215 | 0.65 | TP53 (0.67) | TP53LMNASMN1; SMN2KDM4EHTT | |
| SCHEMBL3155232 | 0.65 | TP53 (0.67) | TP53LMNASMN1; SMN2KDM4EHTT | |
| SCHEMBL20573309 | 0.65 | TP53 (0.74) | TP53LMNASMN1; SMN2KDM4EHTT | |
| SCHEMBL32688308 | 0.65 | TP53 (0.74) | TP53LMNASMN1; SMN2KDM4EHTT | |
| SCHEMBL11513286 | 0.65 | LMNA (0.66) | TP53LMNASMN1; SMN2KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115473-A2 | Substituted pyrrolidinone derivatives and process for their preparation | CIBA-GEIGY AG (CH) | 1984-08-08 | — | — | EP | disclosed |