Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11114617 | 0.89 | KDR (0.48) | MEN1KMT2ASMN1; SMN2ROCK2JAK2 | |
| SCHEMBL11115589 | 0.89 | LMNA (0.57) | MEN1KMT2ASMN1; SMN2L3MBTL1ROCK2 | |
| SCHEMBL11119482 | 0.88 | ROCK2 (0.62) | MGLLROCK2JAK2NTRK1RET | |
| SCHEMBL11116691 | 0.85 | ALDH1A1 (0.45) | MEN1KMT2AL3MBTL1ROCK2JAK2 | |
| SCHEMBL11116974 | 0.82 | MEN1 (0.52) | MEN1KMT2AJAK2NTRK1RET | |
| SCHEMBL11123381 | 0.81 | KDR (0.51) | MEN1KMT2AROCK2JAK2NTRK1 | |
| SCHEMBL11116880 | 0.81 | LMNA (0.54) | MEN1KMT2ASMN1; SMN2L3MBTL1JAK2 | |
| SCHEMBL11117088 | 0.81 | PDGFRB (0.48) | MEN1KMT2AMGLLROCK2JAK2 | |
| SCHEMBL11120834 | 0.80 | AURKB (0.67) | MEN1KMT2AMGLLROCK2JAK2 | |
| SCHEMBL11117737 | 0.80 | JAK2 (0.57) | MEN1KMT2AROCK2JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116853-A1 | Pyridazinones, processes for preparing them, therapeutical compositions containing these compounds and their use | BASF Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |