Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11116531 | 0.85 | MEN1 (0.54) | ROCK2L3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL11115589 | 0.85 | LMNA (0.57) | ROCK2L3MBTL1MEN1KMT2ANPC1 | |
| SCHEMBL11114617 | 0.85 | KDR (0.48) | ROCK2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL11119482 | 0.85 | ROCK2 (0.62) | ROCK2MAPTJAK2NTRK1RET | |
| SCHEMBL11115917 | 0.84 | LMNA (0.46) | ALDH1A1MAPK1MEN1KMT2ANPC1 | |
| SCHEMBL11119372 | 0.81 | JAK2 (0.41) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL3048489 | 0.78 | ALDH1A1 (0.57) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL3103600 | 0.78 | LMNA (0.59) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL11117718 | 0.78 | JAK2 (0.43) | ALDH1A1MAPK1MEN1KMT2ANPC1 | |
| SCHEMBL11116880 | 0.77 | LMNA (0.54) | ALDH1A1L3MBTL1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116853-A1 | Pyridazinones, processes for preparing them, therapeutical compositions containing these compounds and their use | BASF Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |