Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 6/20 | 0.49 |
| ▸ | MAOA | P21397 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL197017 | 0.77 | LMNA (0.72) | GSTP1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL11112000 | 0.77 | L3MBTL1 (0.52) | LMNAMAPTSMN1; SMN2L3MBTL1MCL1 | |
| SCHEMBL9492793 | 0.77 | LMNA (0.56) | GSTP1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL23483029 | 0.75 | LMNA (0.69) | GSTP1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL1096817 | 0.75 | LMNA (0.69) | GSTP1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL731336 | 0.75 | NPC1 (0.50) | LMNAMAOBMAOAMAPTRAB9A | |
| SCHEMBL339813 | 0.75 | LMNA (0.82) | GSTP1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL27367676 | 0.75 | LMNA (0.82) | GSTP1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL9609521 | 0.75 | HTT (0.56) | GSTP1LMNACYP1A2PTGS1SLC6A2 | |
| Benzylphenylether SCHEMBL28285060 | 0.73 | LMNA (0.65) | GSTP1LMNACYP1A2PTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0037062-B1 | SUBSTITUTED 3-ARYL-2-CYCLOALKENE-1-ONES, PROCESS FOR THEIR PREPARATION AND THEIR PARMACEUTICAL USE | Beiersdorf Aktiengesellschaft (DE) | 1984-10-17 | — | — | EP | disclosed |
| US-4401831-A | ADRENOLYTIC AND HYPOTENSIVE AGENTS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1983-08-30 | — | — | US | disclosed |
| US-4358460-A | HYPOTENSIVE, ANTIARRHYTHMIA, ANGINA PECTORIS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1982-11-09 | — | — | US | disclosed |
| EP-0037062-A2 | Substituted 3-aryl-2-cycloalkene-1-ones, process for their preparation and their parmaceutical use | Beiersdorf Aktiengesellschaft (DE) | 1981-10-07 | — | — | EP | disclosed |