Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | DRD2 | P14416 | 8/20 | 0.59 |
| ▸ | DRD3 | P35462 | 8/20 | 0.59 |
| ▸ | DRD4 | P21917 | 4/20 | 0.59 |
| ▸ | DRD1 | P21728 | 3/20 | 0.59 |
| ▸ | HTR2A | P28223 | 3/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1114925 | 0.92 | LMNA (0.63) | LMNAALDH1A1SMN1; SMN2MAPTNLRP1 | |
| SCHEMBL1114848 | 0.90 | HTR1A (0.66) | LMNAALDH1A1SMN1; SMN2MAPTNLRP1 | |
| Hydrochloric Acid SCHEMBL1114721 | 0.89 | HTR1A (0.65) | LMNAALDH1A1SMN1; SMN2MAPTNLRP1 | |
| SCHEMBL1114455 | 0.88 | DRD2 (0.51) | LMNAALDH1A1SMN1; SMN2MAPTNLRP1 | |
| SCHEMBL1114943 | 0.85 | LMNA (0.64) | LMNAALDH1A1SMN1; SMN2MAPTNLRP1 | |
| SCHEMBL1114854 | 0.84 | LMNA (0.69) | LMNAALDH1A1SMN1; SMN2MAPTNLRP1 | |
| SCHEMBL1114497 | 0.83 | DRD2 (0.72) | LMNAALDH1A1SMN1; SMN2MAPTNLRP1 | |
| SCHEMBL27825969 | 0.83 | KCNH2 (0.57) | ALDH1A1SMN1; SMN2MAPTDRD2DRD3 | |
| SCHEMBL1114544 | 0.83 | LMNA (0.64) | LMNAALDH1A1SMN1; SMN2MAPTNLRP1 | |
| SCHEMBL1114437 | 0.83 | LMNA (0.64) | LMNAALDH1A1SMN1; SMN2MAPTNLRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279179-B1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF | SK BIOPHARMACEUTICALS CO LTD (KR) | 2014-09-17 | — | — | EP | claimed |
| US-8772299-B2 | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-07-08 | — | — | US | claimed |
| US-7985752-B2 | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof | SK HOLDINGS CO., LTD. (KR) | 2011-07-26 | — | — | US | claimed |
| US-20110118264-A1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2011-05-19 | — | — | US | claimed |
| EP-2279179-A2 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF | SK Holdings Co., Ltd. (KR) | 2011-02-02 | — | — | EP | claimed |
| US-20090298831-A1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2009-12-03 | — | — | US | claimed |
| WO-2009145591-A2 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF | SK HOLDINGS CO., LTD. (KR) | 2009-12-03 | — | — | WO | claimed |
| EP-2279179-B1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF | SK BIOPHARMACEUTICALS CO LTD (KR) | 2014-09-17 | — | — | EP | disclosed |
| US-8772299-B2 | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-07-08 | — | — | US | disclosed |
| US-8772299-B2 | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-07-08 | — | — | US | disclosed |
| US-8772299-B2 | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-07-08 | — | — | US | disclosed |
| US-7985752-B2 | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof | SK HOLDINGS CO., LTD. (KR) | 2011-07-26 | — | — | US | disclosed |
| US-7985752-B2 | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof | SK HOLDINGS CO., LTD. (KR) | 2011-07-26 | — | — | US | disclosed |
| US-20110118264-A1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2011-05-19 | — | — | US | disclosed |
| US-20110118264-A1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2011-05-19 | — | — | US | disclosed |
| EP-2279179-A2 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF | SK Holdings Co., Ltd. (KR) | 2011-02-02 | — | — | EP | disclosed |
| US-20090298831-A1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2009-12-03 | — | — | US | disclosed |
| US-20090298831-A1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2009-12-03 | — | — | US | disclosed |
| WO-2009145591-A2 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF | SK HOLDINGS CO., LTD. (KR) | 2009-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298831-A1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF | HTR5A, HTR1A, HTR2A | LMNA 2733/4885ALDH1A1 495/4885SMN1; SMN2 2583/4885 |
| US-20110118264-A1 | PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF | HTR5A, HTR1A, HTR2A | LMNA 2590/4885ALDH1A1 523/4885SMN1; SMN2 2545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.