SCHEMBL1114454

SCHEMBL1114454

COc1ccccc1N1CCN(CCCCOc2ccccc2Cn2ccnn2)CC1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.58
KDM4E B2RXH2 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
DRD2 P14416 8/20 0.57
ABCB1 P08183 3/20 0.57
DRD3 P35462 6/20 0.55
DRD1 P21728 2/20 0.55
DRD4 P21917 2/20 0.55
HTR2A P28223 2/20 0.55
LMNA P02545 2/20 0.55
HTR1A P08908 2/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
MAPT P10636 1/20 0.55
NLRP1 Q9C000 1/20 0.55
SLC6A2 P23975 1/20 0.54
SLC6A4 P31645 1/20 0.54
ADRA1A P35348 2/20 0.53
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1114573 0.89 DRD2 (0.52) ALDH1A1KDM4EDRD2DRD3DRD4
SCHEMBL1114544 0.87 LMNA (0.64) ALDH1A1KDM4ETDP1DRD2DRD3
SCHEMBL1114814 0.84 HTR1A (0.66) ALDH1A1DRD2ABCB1DRD3DRD1
SCHEMBL1114351 0.82 LMNA (0.63) ALDH1A1DRD2DRD3DRD1DRD4
SCHEMBL8720336 0.76 ALDH1A1 (0.72) ALDH1A1KDM4ETDP1DRD2DRD3
SCHEMBL8719681 0.76 ALDH1A1 (0.72) ALDH1A1KDM4ETDP1DRD2DRD3
SCHEMBL8719445 0.76 ALDH1A1 (0.72) ALDH1A1KDM4ETDP1DRD2DRD3
SCHEMBL8724501 0.76 ALDH1A1 (0.72) ALDH1A1KDM4ETDP1DRD2DRD3
SCHEMBL3612087 0.76 ALDH1A1 (0.62) ALDH1A1KDM4ETDP1DRD2DRD3
SCHEMBL3614806 0.76 DRD2 (0.71) ALDH1A1KDM4ETDP1DRD2DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2279179-A2 PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF SK Holdings Co., Ltd. (KR) 2011-02-02 EP claimed
WO-2009145591-A2 PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF SK HOLDINGS CO., LTD. (KR) 2009-12-03 WO claimed
EP-2279179-A2 PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF SK Holdings Co., Ltd. (KR) 2011-02-02 EP disclosed
WO-2009145591-A2 PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF SK HOLDINGS CO., LTD. (KR) 2009-12-03 WO disclosed