Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11155793 | 0.88 | DRD2 (0.45) | KMT2AMEN1OPRM1OPRL1DRD2 | |
| SCHEMBL11151306 | 0.86 | OPRL1 (0.54) | ALDH1A1KMT2AMEN1TP53OPRM1 | |
| SCHEMBL11155212 | 0.86 | OPRM1 (0.51) | ALDH1A1KMT2AMEN1OPRM1OPRL1 | |
| SCHEMBL11149158 | 0.84 | MC4R (0.42) | KMT2AMEN1NPC1TP53OPRM1 | |
| SCHEMBL11266008 | 0.84 | DRD2 (0.37) | ALDH1A1KMT2AMEN1L3MBTL1OPRL1 | |
| SCHEMBL11165081 | 0.84 | CYP2D6 (0.50) | TDP1KMT2AMEN1NPC1 | |
| SCHEMBL11156259 | 0.82 | KMT2A (0.49) | ALDH1A1TDP1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL11154795 | 0.82 | DRD2 (0.40) | KMT2AMEN1OPRL1DRD2 | |
| SCHEMBL11153010 | 0.81 | CYP2D6 (0.44) | KDM4EKMT2AMEN1OPRM1OPRK1 | |
| SCHEMBL11153780 | 0.80 | KMT2A (0.44) | ALDH1A1TDP1KMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0023706-B1 | 4-PHENOXY PIPERIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICAMENTS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |
| US-4333942-A | Anti-depressant and analgesic 4-phenoxypiperidines | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-06-08 | — | — | US | disclosed |
| EP-0023706-A1 | 4-Phenoxy piperidines, process for their preparation, their use and medicaments containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |