Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11149109 | 0.84 | KDM4E (0.47) | DRD2MEN1KMT2AOPRL1POLB | |
| SCHEMBL11151306 | 0.82 | OPRL1 (0.54) | MEN1KMT2AOPRL1POLBCYP3A4 | |
| SCHEMBL11155793 | 0.82 | DRD2 (0.45) | DRD2MEN1KMT2AOPRL1SIGMAR1 | |
| SCHEMBL11149158 | 0.81 | MC4R (0.42) | DRD2MEN1KMT2AOPRL1SIGMAR1 | |
| SCHEMBL11165081 | 0.81 | CYP2D6 (0.50) | MEN1KMT2ACYP3A4USP2CYP2D6 | |
| SCHEMBL11155212 | 0.80 | OPRM1 (0.51) | DRD2MEN1KMT2AOPRL1ALDH1A1 | |
| SCHEMBL11154795 | 0.78 | DRD2 (0.40) | DRD2MEN1KMT2AOPRL1CYP2D6 | |
| SCHEMBL11153010 | 0.78 | CYP2D6 (0.44) | MEN1KMT2AOPRL1CYP2D6SIGMAR1 | |
| SCHEMBL11150819 | 0.77 | OPRM1 (0.39) | DRD2OPRL1 | |
| SCHEMBL16546692 | 0.77 | POLB (0.39) | MEN1KMT2AOPRL1POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4333942-A | Anti-depressant and analgesic 4-phenoxypiperidines | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-06-08 | — | — | US | disclosed |
| EP-0023706-A1 | 4-Phenoxy piperidines, process for their preparation, their use and medicaments containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |