Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11149109 | 0.86 | KDM4E (0.47) | OPRL1POLBALDH1A1MEN1KMT2A | |
| SCHEMBL11155793 | 0.84 | DRD2 (0.45) | OPRL1SIGMAR1MEN1KMT2AOPRM1 | |
| SCHEMBL11149158 | 0.83 | MC4R (0.42) | OPRL1SIGMAR1MEN1KMT2AOPRM1 | |
| SCHEMBL11153010 | 0.82 | CYP2D6 (0.44) | OPRL1SIGMAR1CYP2D6MEN1KMT2A | |
| SCHEMBL11165081 | 0.82 | CYP2D6 (0.50) | CYP3A4CYP2D6USP2MAPK1CYP2C9 | |
| SCHEMBL11266008 | 0.82 | DRD2 (0.37) | OPRL1CYP3A4HSD17B10POLBSIGMAR1 | |
| SCHEMBL11155212 | 0.81 | OPRM1 (0.51) | OPRL1SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL11154795 | 0.80 | DRD2 (0.40) | OPRL1SIGMAR1CYP2D6MEN1KMT2A | |
| SCHEMBL11164837 | 0.79 | OPRL1 (0.47) | OPRL1SIGMAR1OPRM1 | |
| SCHEMBL11155399 | 0.78 | OPRL1 (0.58) | OPRL1CYP3A4HSD17B10POLBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0023706-B1 | 4-PHENOXY PIPERIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICAMENTS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |
| US-4333942-A | Anti-depressant and analgesic 4-phenoxypiperidines | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-06-08 | — | — | US | disclosed |
| EP-0023706-A1 | 4-Phenoxy piperidines, process for their preparation, their use and medicaments containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |