Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11164837 | 0.93 | OPRL1 (0.47) | SIGMAR1OPRM1OPRK1OPRL1 | |
| SCHEMBL11151306 | 0.82 | OPRL1 (0.54) | CYP2D6SIGMAR1MEN1KMT2AOPRM1 | |
| SCHEMBL11149109 | 0.81 | KDM4E (0.47) | KDM4EMEN1KMT2AOPRM1OPRK1 | |
| SCHEMBL11155793 | 0.79 | DRD2 (0.45) | SIGMAR1MEN1KMT2AOPRM1OPRL1 | |
| SCHEMBL11149158 | 0.78 | MC4R (0.42) | HRH3SIGMAR1MEN1KMT2AOPRM1 | |
| SCHEMBL11266008 | 0.78 | DRD2 (0.37) | CYP2D6SIGMAR1MEN1KMT2AOPRL1 | |
| SCHEMBL11165081 | 0.78 | CYP2D6 (0.50) | CYP2D6HRH3MEN1KMT2A | |
| SCHEMBL11153352 | 0.77 | SIGMAR1 (0.47) | CYP2D6HRH1HRH3SIGMAR1EPHX2 | |
| SCHEMBL11155212 | 0.77 | OPRM1 (0.51) | SIGMAR1MEN1KMT2AOPRM1OPRL1 | |
| SCHEMBL11154795 | 0.76 | DRD2 (0.40) | CYP2D6SIGMAR1MEN1KMT2AOPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0023706-B1 | 4-PHENOXY PIPERIDINES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICAMENTS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |
| US-4333942-A | Anti-depressant and analgesic 4-phenoxypiperidines | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-06-08 | — | — | US | disclosed |
| EP-0023706-A1 | 4-Phenoxy piperidines, process for their preparation, their use and medicaments containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |