SCHEMBL12314599

SCHEMBL12314599

Cn1c(=O)n(CCCn2c(=O)n(C)c3cc(N)c([N+](=O)[O-])cc32)c2cc(N)c([N+](=O)[O-])cc21

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 7/20 0.50
▸ KDM4E B2RXH2 1/20 0.50
▸ LMNA P02545 1/20 0.50
▸ HTT P42858 1/20 0.50
▸ NPSR1 Q6W5P4 1/20 0.50
▸ ATAD2 Q6PL18 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ ALDH1A1 P00352 3/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ S100B P04271 1/20 0.40
▸ TSHR P16473 2/20 0.38
▸ TDP1 Q9NUW8 4/20 0.38
▸ MPI P34949 1/20 0.38
▸ CYP1A2 P05177 1/20 0.38
▸ CYP2C9 P11712 1/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ PKM P14618 1/20 0.38
▸ SIRT6 Q8N6T7 1/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1115708 0.89 MAPT (0.62) MAPTKDM4ELMNAHTTNPSR1
SCHEMBL1115747 0.88 MAPT (0.59) MAPTKDM4ELMNAHTTNPSR1
SCHEMBL1115528 0.87 ALDH1A1 (0.42) MAPTKDM4ELMNAHTTNPSR1
SCHEMBL1115798 0.81 MAPT (0.76) MAPTKDM4ELMNAHTTNPSR1
SCHEMBL1115725 0.81 MAPT (0.40) MAPTKDM4ELMNAHTTNPSR1
SCHEMBL1115720 0.75 MAPT (0.47) MAPTKDM4ELMNAHTTNPSR1
SCHEMBL12338148 0.73 ATAD2 (0.45) MAPTKDM4EATAD2ALDH1A1KMT2A
SCHEMBL30349789 0.73 MAPT (0.61) MAPTKDM4ELMNAHTTNPSR1
SCHEMBL20569191 0.70 MAPT (0.42) MAPTKDM4ELMNAHTTNPSR1
SCHEMBL8129306 0.70 MAPT (0.42) MAPTKDM4ELMNAHTTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8262949-B2 Long wavelength shifted benzotriazole uv-absorbers and their use BASF SE (DE) 2012-09-11 — — US disclosed
US-8262949-B2 Long wavelength shifted benzotriazole uv-absorbers and their use BASF SE (DE) 2012-09-11 — — US disclosed
EP-2032577-B1 LONG WAVELENGTH SHIFTED BENZOTRIAZOLE UV-ABSORBERS AND THEIR USE BASF SE (DE) 2011-02-02 — — EP disclosed
US-20100163813-A1 Long wavelength shifted benzotriazole uv-absorbers and their use CIBA CORPORATION 2010-07-01 — — US disclosed
WO-2008000646-A1 LONG WAVELENGTH SHIFTED BENZOTRIAZOLE UV-ABSORBERS AND THEIR USE CIBA HOLDING INC. (CH) 2008-01-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100163813-A1 Long wavelength shifted benzotriazole uv-absorbers and their use SULT1A1, GABBR1, TPMT MAPT 136/4885KDM4E 626/4885LMNA 1593/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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