Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11203944 | 0.87 | ALDH1A1 (0.42) | GAACYP3A4CYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL11219438 | 0.73 | SLC6A2 (0.40) | ALDH1A1L3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11092419 | 0.72 | ALDH1A1 (0.41) | GAACYP3A4CYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL11089455 | 0.69 | ALDH1A1 (0.38) | GAACYP3A4CYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL11095711 | 0.69 | CYP3A4 (0.40) | GAACYP3A4CYP2C19ALDH1A1MAPT | |
| SCHEMBL11087533 | 0.67 | ALDH1A1 (0.37) | GAACYP3A4CYP2C19ALDH1A1MAPT | |
| SCHEMBL9413499 | 0.66 | ALDH1A1 (0.66) | CYP3A4CYP2C19CYP2C9ALDH1A1L3MBTL1 | |
| SCHEMBL11622951 | 0.64 | ALDH1A1 (0.41) | GAACYP3A4CYP2C19CYP2C9ALDH1A1 | |
| SCHEMBL11640160 | 0.64 | ALDH1A1 (0.42) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL24598759 | 0.64 | TEAD1 (0.54) | ALDH1A1HIF1AEPAS1AKR1C3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0010347-B1 | NOVEL SUBSTITUTED OMEGA-AROYL(PROPIONYL OR BUTYRYL)-L-PROLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | AMERICAN CYANAMID COMPANY (US) | 1983-11-09 | — | — | EP | disclosed |
| US-4226775-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1980-10-07 | — | — | US | disclosed |