Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PRKDC | P78527 | 4/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11203944 | 0.80 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL11157410 | 0.73 | GAA (0.43) | SLC6A4L3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL11221521 | 0.66 | SLC6A2 (0.55) | SLC6A2SLC6A4L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11224434 | 0.62 | BCL2L1 (0.50) | RAB9ALMNA | |
| SCHEMBL6752314 | 0.61 | L3MBTL1 (0.54) | SLC6A2SLC6A4L3MBTL1SMN1; SMN2PRKDC | |
| SCHEMBL14775525 | 0.60 | SLC6A2 (0.71) | SLC6A2SLC6A4L3MBTL1ADRB2CYP2A6 | |
| SCHEMBL27839304 | 0.60 | SLC6A2 (0.53) | SLC6A2SLC6A4L3MBTL1ADRB2CYP2A6 | |
| SCHEMBL11092419 | 0.59 | ALDH1A1 (0.41) | L3MBTL1ALDH1A1SMN1; SMN2NPC1LMNA | |
| SCHEMBL2388308 | 0.58 | MGLL (0.44) | ADRB2CYP2A6LMNA | |
| SCHEMBL274427 | 0.58 | CYP2A6 (0.58) | ADRB2CYP2A6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4342690-A | HHYPOTENSIVE AGE TS | AMERICAN CYANAMID COMPANY (US) | 1982-08-03 | — | — | US | disclosed |
| US-4342689-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1982-08-03 | — | — | US | disclosed |
| US-4342691-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1982-08-03 | — | — | US | disclosed |
| US-4299769-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1981-11-10 | — | — | US | disclosed |