Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28024587 | 0.81 | IKBKB (0.41) | IKBKBCHUKCA1CA2MAP4K4 | |
| SCHEMBL28835971 | 0.80 | ENPP1 (0.45) | RAB9AIKBKBCHUKNPC1CA1 | |
| SCHEMBL11901043 | 0.79 | MAP4K4 (0.48) | RAB9ANPC1KDRMAP4K4LRRK2 | |
| SCHEMBL28353139 | 0.76 | TBXA2R (0.47) | CA1CA2KDRMAP4K4ABL1 | |
| SCHEMBL11821346 | 0.74 | KMO (0.51) | RAB9ANPC1KDRMAP4K4LRRK2 | |
| SCHEMBL6743007 | 0.74 | FEN1 (0.41) | RAB9ANPC1CA1CA2LRRK2 | |
| SCHEMBL4582784 | 0.73 | MAP4K4 (0.69) | RAB9ANPC1KDRMAP4K4LRRK2 | |
| SCHEMBL15865105 | 0.73 | CYP17A1 (0.39) | IKBKBCHUKCA1CA2ADORA1 | |
| SCHEMBL28960689 | 0.70 | HEXA (0.46) | RAB9ANPC1KDRMAP4K4LRRK2 | |
| SCHEMBL19475077 | 0.69 | ALOX5AP (0.46) | RAB9ANPC1CA1CA2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115010659-A | New impurity reference substance of torasemide and preparation method thereof | 南京正科医药股份有限公司 | 2022-09-06 | — | — | CN | claimed |
| CN-115417810-B | Refining method of torsemide crystal form I | 南京正科医药股份有限公司 | 2023-10-10 | — | — | CN | disclosed |
| CN-115417810-A | Refining method of torasemide crystal form I | 南京正科医药股份有限公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-115010659-A | New impurity reference substance of torasemide and preparation method thereof | 南京正科医药股份有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-110606826-B | Torasemide sodium monohydrate, crystal forms and compositions thereof | 上海勋和医药科技有限公司 | 2021-06-01 | — | — | CN | disclosed |
| CN-110606826-A | Torasemide sodium monohydrate, crystal forms and compositions thereof | 上海勋和医药科技有限公司 | 2019-12-24 | — | — | CN | disclosed |
| CN-102702089-B | Method for preparing high-purity torasemide and crystal form I thereof | LIANYUNGANG JARI PHARMACEUTICAL CO LTD | 2014-08-27 | — | — | CN | disclosed |
| CN-102702089-A | Method for preparing high-purity torasemide and crystal form I thereof | LIANYUNGANG JARI PHARMACEUTICAL CO LTD | 2012-10-03 | — | — | CN | disclosed |
| EP-0003383-B1 | 4-AMINO-3-SULFONAMIDO PYRIDINE DERIVATIVES | A. CHRISTIAENS SOCIETE ANONYME (BE) | 1983-02-09 | — | — | EP | disclosed |
| EP-0003383-A2 | 4-Amino-3-sulfonamido pyridine derivatives | A. CHRISTIAENS SOCIETE ANONYME (BE) | 1979-08-08 | — | — | EP | disclosed |