Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | TARS1 | P26639 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | LARS1 | Q9P2J5 | 2/20 | 0.39 |
| ▸ | FBP1 | P09467 | 8/20 | 0.38 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.38 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11158123 | 0.76 | RAB9A (0.43) | KDRCA12CA1CA2CA9 | |
| SCHEMBL11821346 | 0.69 | KMO (0.51) | KDRPLK4AURKAROCK2RPS6KA5 | |
| SCHEMBL28835971 | 0.69 | ENPP1 (0.45) | KDRCA1CA2MAP4K4ABL1 | |
| SCHEMBL11901043 | 0.68 | MAP4K4 (0.48) | KDM4EKDRMAP4K4ABL1LCK | |
| SCHEMBL19332530 | 0.68 | CA2 (0.51) | NLRP3FBP1CA12CA1CA2 | |
| SCHEMBL29433655 | 0.67 | TBXA2R (0.66) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| SCHEMBL10460903 | 0.66 | TBXA2R (0.62) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| SCHEMBL28827564 | 0.65 | TBXA2R (0.45) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| Torsemide SCHEMBL4015063 | 0.64 | TBXA2R (1.00) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A | |
| Torsemide SCHEMBL41184 | 0.64 | TBXA2R (1.00) | TBXA2RKDM4ECYP3A4CYP2C9HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115137696-A | Torasemide injection and preparation method thereof | 南京力博维制药有限公司 | 2022-10-04 | — | — | CN | disclosed |
| CN-110606860-B | Pyridine sulfonamide phosphate compound, preparation method and application thereof | 上海勋和医药科技有限公司 | 2021-12-10 | — | — | CN | disclosed |
| CN-110054647-B | Torasemide phosphate prodrugs, preparation method and composition thereof | 上海勋和医药科技有限公司 | 2021-06-15 | — | — | CN | disclosed |
| CN-110606826-B | Torasemide sodium monohydrate, crystal forms and compositions thereof | 上海勋和医药科技有限公司 | 2021-06-01 | — | — | CN | disclosed |
| CN-110606826-A | Torasemide sodium monohydrate, crystal forms and compositions thereof | 上海勋和医药科技有限公司 | 2019-12-24 | — | — | CN | disclosed |
| CN-110606860-A | Pyridine sulfonamide phosphate compound, preparation method and application thereof | 上海勋和医药科技有限公司 | 2019-12-24 | — | — | CN | disclosed |