Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.52 |
| ▸ | HTR2A | P28223 | 4/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 2/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.46 |
| ▸ | QPCT | Q16769 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11184745 | 0.91 | DRD2 (0.51) | HTR1AHTR2ADRD2ADRA1ADRD3 | |
| SCHEMBL11166971 | 0.90 | L3MBTL1 (0.54) | DRD2ADRA1ADRD3ALOX15MAPT | |
| SCHEMBL11167746 | 0.90 | MAPT (0.55) | HTR1ADRD2ADRA1ADRD3QPCT | |
| SCHEMBL11165239 | 0.89 | HTR2A (0.58) | HTR1AHTR2ADRD2METALOX15 | |
| SCHEMBL11171069 | 0.87 | QPCT (0.52) | HTR1ADRD2ADRA1ADRD3QPCT | |
| SCHEMBL11170034 | 0.81 | HTR2A (0.57) | HTR1AHTR2ADRD2QPCTMAPT | |
| SCHEMBL11172796 | 0.79 | HTR2A (0.57) | HTR1AHTR2ADRD2ADRA1ADRD3 | |
| SCHEMBL11170700 | 0.79 | MAPT (0.57) | HTR1AHTR2ADRD2ALOX15MAPT | |
| SCHEMBL11165829 | 0.79 | DRD2 (0.62) | HTR1AHTR2ADRD2QPCTMAPT | |
| SCHEMBL11157326 | 0.79 | ALDH1A1 (0.54) | HTR1ADRD2QPCTMAPTMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4413006-A | N-Aryl-N-phenoxy-alkyl-piperazine compounds useful in decreasing intracranial pressure | TANABE SEIYAKU CO., LTD. (JP) | 1983-11-01 | — | — | US | disclosed |
| EP-0034284-B1 | PIPERAZINE DERIVATIVE, PROCESSES FOR PREPARING THE SAME AND THERAPEUTIC COMPOSITIONS CONTAINING IT | Tanabe Seiyaku Co., Ltd. (JP) | 1983-10-05 | — | — | EP | disclosed |
| EP-0034284-A2 | Piperazine derivative, processes for preparing the same and therapeutic compositions containing it | Tanabe Seiyaku Co., Ltd. (JP) | 1981-08-26 | — | — | EP | disclosed |