Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1224966 | 0.88 | TLR8 (0.41) | NPC1RAB9ASMN1; SMN2LMNACYP1A2 | |
| SCHEMBL11163369 | 0.81 | LMNA (0.35) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25419023 | 0.78 | HSD17B10 (0.36) | NPC1RAB9ASMN1; SMN2LMNAHPGD | |
| SCHEMBL11169323 | 0.74 | CYP3A4 (0.38) | NPC1HPGDPDE4APDE4BPDE4C | |
| SCHEMBL11174630 | 0.74 | — | — | |
| SCHEMBL11163016 | 0.70 | SMN1; SMN2 (0.44) | RAB9ASMN1; SMN2LMNAHPGDTSHR | |
| SCHEMBL18161040 | 0.66 | TYR (0.38) | NPC1RAB9ASMN1; SMN2LMNAHPGD | |
| SCHEMBL13341567 | 0.64 | AGBL2 (0.32) | — | |
| SCHEMBL9483858 | 0.64 | L3MBTL1 (0.46) | TSHRCYP1A2CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL21546149 | 0.62 | EP300 (0.44) | HPGDTYRADORA2AADORA2BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4395406-A | 5-Halopyrimid-2-ones | NYEGAARD & CO. A/S (NO) | 1983-07-26 | — | — | US | claimed |
| US-4395406-A | 5-Halopyrimid-2-ones | NYEGAARD & CO. A/S (NO) | 1983-07-26 | — | — | US | disclosed |