Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11622916 | 0.81 | USP7 (0.46) | MAP4K4MEN1PSIP1AXLMKNK1 | |
| SCHEMBL30522572 | 0.80 | UHRF1 (0.45) | MAP4K4MEN1FYNNPC1RAB9A | |
| SCHEMBL11254473 | 0.80 | UHRF1 (0.45) | MAP4K4MEN1FYNNPC1RAB9A | |
| SCHEMBL12305117 | 0.80 | CYP2A6 (0.47) | MEN1NPC1RAB9ATSHRUHRF1 | |
| SCHEMBL11375205 | 0.79 | HSD17B1 (0.50) | FYN | |
| SCHEMBL14287994 | 0.79 | MAOA (0.54) | MAP4K4MEN1PSIP1AXLMKNK1 | |
| SCHEMBL11185053 | 0.76 | MEN1 (0.56) | MAP4K4MEN1PSIP1AXLMKNK1 | |
| SCHEMBL9677424 | 0.76 | PLA2G7 (0.52) | MAP4K4MAOATSHRRECQL | |
| SCHEMBL25756400 | 0.76 | FGFR1 (0.44) | MAP4K4UHRF1 | |
| SCHEMBL21982143 | 0.76 | L3MBTL1 (0.46) | MAP4K4MEN1FYNNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4377585-A | Use of 4-[4(or 3)-aminophenyl]pyridines as cardiotonic agents | STERLING DRUG INC. (US) | 1983-03-22 | — | — | US | disclosed |
| US-4376775-A | N-[4-(4-Pyridinyl)phenyl]ureas and their cardiotonic use | STERLING DRUG INC. (US) | 1983-03-15 | — | — | US | disclosed |
| US-4317827-A | 4-[4(or 3)-Acylaminophenyl]pyridines and their use as cardiotonics | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4297363-A | 2-Amino-3(4 or 5)-(pyridinyl)phenols and their use as cardiotonics | STERLING DRUG INC. (US) | 1981-10-27 | — | — | US | disclosed |