Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11213997 | 0.86 | KMT2A (0.33) | SMN1; SMN2POLBKMT2APDE5ALMNA | |
| SCHEMBL11259834 | 0.83 | PDE5A (0.33) | SMN1; SMN2POLBKMT2APDE5ALMNA | |
| SCHEMBL11186430 | 0.80 | ALDH1A1 (0.44) | POLBALDH1A1FFAR2HSD17B10 | |
| SCHEMBL11184570 | 0.79 | POLB (0.47) | POLBKMT2AALDH1A1FFAR2HSD17B10 | |
| SCHEMBL11222613 | 0.79 | POLB (0.42) | SMN1; SMN2POLBKMT2APDE5ALMNA | |
| SCHEMBL10944369 | 0.79 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBKMT2ALMNAALDH1A1 | |
| SCHEMBL10942665 | 0.79 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBKMT2ALMNAALDH1A1 | |
| SCHEMBL11199916 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2POLBKMT2APDE5ALMNA | |
| SCHEMBL11190490 | 0.79 | HTT (0.42) | POLBKMT2AHTTFFAR2HSD17B10 | |
| SCHEMBL10942943 | 0.77 | L3MBTL1 (0.43) | SMN1; SMN2POLBKMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | claimed |
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |