Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | QDPR | P09417 | 2/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11199610 | 0.87 | TUBB4A (0.38) | GAAPOLBRAB9AATMFFAR2 | |
| SCHEMBL11184581 | 0.82 | POLB (0.40) | GAAPOLBRAB9AFFAR2 | |
| SCHEMBL11263001 | 0.81 | POLB (0.40) | GAAPOLBRAB9AFFAR2KDM4E | |
| SCHEMBL11202283 | 0.79 | POLB (0.38) | GAAPOLBRAB9AFFAR2KDM4E | |
| SCHEMBL11201160 | 0.78 | GAA (0.47) | GAAPOLBRAB9ATSHRQDPR | |
| SCHEMBL11219804 | 0.78 | ACE (0.36) | POLBFFAR2 | |
| SCHEMBL11194045 | 0.77 | ACE (0.51) | POLBFFAR2 | |
| SCHEMBL11109577 | 0.77 | GAA (0.47) | GAAPOLBRAB9ATSHRFFAR2 | |
| SCHEMBL11189268 | 0.77 | ALDH1A1 (0.44) | POLBKDM4E | |
| SCHEMBL11199916 | 0.76 | SMN1; SMN2 (0.44) | GAAPOLBRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |