SCHEMBL11201765

SCHEMBL11201765

CC(NCC(O)Cc1cccc2c1OCCO2)NC(=O)C(C)c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 7/20 0.43
NPC1 O15118 1/20 0.36
POLB P06746 1/20 0.36
RAB9A P51151 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
PSMB5 P28074 2/20 0.36
CYP3A4 P08684 2/20 0.35
CYP2D6 P10635 2/20 0.35
CYP2C9 P11712 2/20 0.35
ROCK2 O75116 1/20 0.35
ROCK1 Q13464 1/20 0.35
USP9X Q93008 1/20 0.34
PTGS1 P23219 1/20 0.34
PTGS2 P35354 1/20 0.34
CYP1A2 P05177 1/20 0.34
MAPT P10636 1/20 0.34
HPGD P15428 1/20 0.34
CYP2C19 P33261 1/20 0.34
GPR88 Q9GZN0 1/20 0.34
GRM7 Q14831 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11201763 0.75 MTNR1A (0.45) MTNR1ANPC1RAB9ASMN1; SMN2CYP3A4
SCHEMBL11204323 0.72 ADRB2 (0.39) SMN1; SMN2CYP2D6CYP2C9CYP1A2
SCHEMBL11655879 0.71 ADRB1 (0.48) NPC1RAB9ASMN1; SMN2GPR88
SCHEMBL11652659 0.71 ADRB1 (0.48) NPC1RAB9ASMN1; SMN2GPR88
SCHEMBL11652087 0.71 ADRB1 (0.48) NPC1RAB9ASMN1; SMN2GPR88
SCHEMBL11201767 0.69 MTNR1A (0.42) MTNR1ANPC1RAB9ASMN1; SMN2CYP3A4
SCHEMBL7268290 0.69 MTNR1A (0.56) MTNR1ACYP3A4CYP2D6CYP2C9ROCK2
SCHEMBL10148115 0.68 MTNR1A (0.54) MTNR1ACYP3A4CYP2D6CYP2C9ROCK2
SCHEMBL11655170 0.63 GPR88 (0.43) GPR88
SCHEMBL11655464 0.63 GPR88 (0.43) GPR88

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4387099-A Alkanolamine derivatives IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1983-06-07 US disclosed
US-4327113-A DRUGS FOR TREATMENT OF HEART DISEASES, ADRENERGIC BLOCKING AGENTS, ETC IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1982-04-27 US disclosed
US-4260632-A ADRENERGIC BLOCKING AGENTS, CARDIOVASCULAR DISORDERS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1981-04-07 US disclosed
US-4221807-A ADRENERGIC BLOCKING AGENTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-09-09 US disclosed
US-4141987-A HYPOTENSIVE, ADRENERGIC BLOCKING AGENT IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1979-02-27 US disclosed