SCHEMBL11205593

SCHEMBL11205593

CCOC(=O)OC1(CCCCCCCc2ccc(C(F)(F)F)cc2)CO1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
PLK1 P53350 1/20 0.39
NAAA Q02083 1/20 0.39
KDM4E B2RXH2 2/20 0.38
ALDH1A1 P00352 1/20 0.38
FAAH O00519 1/20 0.36
KCNQ3 O43525 1/20 0.36
KCNQ2 O43526 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
EPHX2 P34913 1/20 0.35
PPARG P37231 1/20 0.35
PPARD Q03181 1/20 0.35
PPARA Q07869 1/20 0.35
MEN1 O00255 1/20 0.35
HSP90AA1 P07900 1/20 0.35
MAPT P10636 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11201942 0.87 THRA (0.36) NAAAKDM4ENPSR1CYP1A2CYP2C9
SCHEMBL11206652 0.87 THRA (0.36) NAAAKDM4ENPSR1CYP1A2CYP2C9
SCHEMBL11022010 0.86 ABCB11 (0.50) CYP1A2CYP2C9CYP2C19EPHX2PPARG
SCHEMBL11208706 0.85 MAPT (0.48) HDAC1HDAC8NAAAALDH1A1CYP1A2
SCHEMBL7359104 0.85 MAPT (0.48) HDAC1HDAC8NAAAALDH1A1CYP1A2
SCHEMBL11203299 0.85 KCNA3 (0.41) ALDH1A1MEN1MAPTKMT2A
SCHEMBL11201202 0.85 KCNA3 (0.41) ALDH1A1MEN1MAPTKMT2A
SCHEMBL11206024 0.85 KCNA3 (0.41) ALDH1A1MEN1MAPTKMT2A
SCHEMBL11208527 0.85 KCNA3 (0.41) ALDH1A1MEN1MAPTKMT2A
SCHEMBL11206453 0.84 KMT2A (0.44) ALDH1A1CYP2C19MEN1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0025192-B1 SUBSTITUTED OXIRANE CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES CONTAINING THEM Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1983-05-11 EP disclosed
EP-0025192-A2 Substituted oxirane carboxylic acids, process for their preparation, their use and medicines containing them Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1981-03-18 EP disclosed