Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 3/20 | 0.33 |
| ▸ | KHK | P50053 | 2/20 | 0.33 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11207423 | 1.00 | P2RY12 (0.35) | P2RY12KDM4EALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL11202792 | 0.90 | KHK (0.38) | P2RY12KDM4EALDH1A1KHKHTR2A | |
| SCHEMBL11205682 | 0.82 | KDM4E (0.37) | KDM4EALDH1A1HTR2AMAPTHTT | |
| SCHEMBL11201865 | 0.80 | ALDH1A1 (0.39) | P2RY12KDM4EALDH1A1HSD17B10KHK | |
| SCHEMBL11203991 | 0.79 | HTR2A (0.38) | P2RY12KDM4EALDH1A1KHKHTR2A | |
| SCHEMBL11199749 | 0.78 | HRH4 (0.36) | KDM4EALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL11203366 | 0.76 | KHK (0.41) | KDM4EALDH1A1KHKHTR2AMAPT | |
| SCHEMBL11201723 | 0.76 | KHK (0.39) | P2RY12KDM4EALDH1A1KHKHTR2A | |
| SCHEMBL11203967 | 0.76 | KDM4E (0.38) | P2RY12KDM4EALDH1A1IKBKBCHUK | |
| SCHEMBL11197095 | 0.74 | CETP (0.39) | P2RY12KDM4EALDH1A1IKBKBKHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0082023-A2 | Thienopyrimidine derivatives, their preparation and their medical use | SANKYO COMPANY LIMITED (JP) | 1983-06-22 | — | — | EP | disclosed |