Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 11/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8664406 | 0.80 | HIF1A (0.40) | HIF1ASMN1; SMN2TP53MAPTKDM4E | |
| SCHEMBL11210561 | 0.80 | HIF1A (0.45) | HIF1ASMN1; SMN2TP53MAPTNQO1 | |
| SCHEMBL11208465 | 0.79 | HIF1A (0.44) | HIF1ASMN1; SMN2TP53MAPTNQO1 | |
| SCHEMBL24796249 | 0.77 | FAAH (0.39) | HIF1ASMN1; SMN2TP53MAPTKDM4E | |
| SCHEMBL11211287 | 0.76 | ATM (0.43) | HIF1ASMN1; SMN2TP53MAPTKDM4E | |
| SCHEMBL5096529 | 0.75 | HIF1A (0.41) | HIF1ASMN1; SMN2TP53MAPTNQO1 | |
| SCHEMBL10645672 | 0.70 | HIF1A (0.41) | HIF1ASMN1; SMN2TP53MAPTKDM4E | |
| SCHEMBL8997426 | 0.70 | ALDH1A1 (0.64) | SMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL7512529 | 0.70 | ALDH1A1 (0.64) | SMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL7512534 | 0.70 | ALDH1A1 (0.64) | SMN1; SMN2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0094833-A2 | Novel 1,2-benzisoxazole derivatives | Dainippon Pharmaceutical Co., Ltd. (JP) | 1983-11-23 | — | — | EP | disclosed |