SCHEMBL11208902

SCHEMBL11208902

CC1(C)C(=O)CN(c2ccccc2)C1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.46
NPC1 O15118 3/20 0.46
MAPT P10636 2/20 0.46
KDM4E B2RXH2 1/20 0.46
GAA P10253 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.42
DDB1 Q16531 1/20 0.42
CRBN Q96SW2 1/20 0.42
HSD11B1 P28845 1/20 0.41
PGR P06401 1/20 0.41
ELANE P08246 3/20 0.40
UGCG Q16739 1/20 0.39
ALDH1A1 P00352 3/20 0.38
CTSG P08311 2/20 0.38
CMA1 P23946 2/20 0.38
PKM P14618 1/20 0.38
CYP1A2 P05177 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11812858 0.70 PGR (0.50) KDM4EGAAMEN1KMT2APGR
SCHEMBL9834330 0.69 KMT2A (0.61) RAB9ANPC1MAPTKDM4EGAA
SCHEMBL6410939 0.69 HSD11B1 (0.53) RAB9ANPC1MAPTKDM4EGAA
SCHEMBL3207582 0.69 ELANE (0.56) GAAMEN1KMT2ADDB1CRBN
SCHEMBL3190789 0.69 KMT2A (0.44) KMT2AHSD11B1ALDH1A1HPGD
SCHEMBL10948887 0.69 ELANE (0.63) GAAPGRELANEALDH1A1
SCHEMBL29332297 0.69 ELANE (0.50) KDM4EMEN1KMT2ASMN1; SMN2PGR
SCHEMBL22055779 0.67 CTSG (0.45) RAB9AMAPTKDM4EGAATDP1
SCHEMBL24700453 0.67 DDB1 (0.47) RAB9ANPC1MAPTKDM4EGAA
SCHEMBL22055646 0.67 RAB9A (0.52) RAB9ANPC1MAPTKDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0088259-A2 Azolyl-pyrrolidinones, process for their preparation and their use as fungicides Consortium für elektrochemische Industrie GmbH (DE) 1983-09-14 EP disclosed