Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 6/20 | 0.40 |
| ▸ | CES1 | P23141 | 4/20 | 0.36 |
| ▸ | FAAH | O00519 | 3/20 | 0.36 |
| ▸ | FABP3 | P05413 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552115 | 0.98 | CES2 (0.39) | CES2CES1FAAHEPHX1CA1 | |
| SCHEMBL7967481 | 0.98 | CES2 (0.39) | CES2CES1FAAHEPHX1CA1 | |
| SCHEMBL2957022 | 0.98 | CES2 (0.39) | CES2CES1FAAHEPHX1CA1 | |
| SCHEMBL10993074 | 0.98 | CES2 (0.39) | CES2CES1FAAHEPHX1CA1 | |
| SCHEMBL339202 | 0.98 | CES2 (0.39) | CES2CES1FAAHEPHX1CA1 | |
| SCHEMBL2729135 | 0.98 | CES2 (0.39) | CES2CES1FAAHEPHX1CA1 | |
| SCHEMBL1666274 | 0.98 | CES2 (0.39) | CES2CES1FAAHEPHX1CA1 | |
| SCHEMBL219970 | 0.98 | CES2 (0.39) | CES2CES1FAAHEPHX1CA1 | |
| SCHEMBL11432185 | 0.98 | CES2 (0.39) | CES2CES1FAAHEPHX1CA1 | |
| Potassium Ion SCHEMBL8777179 | 0.98 | CES2 (0.39) | CES2CES1FAAHFABP3EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005215-B1 | PROCESS FOR POLYMERIZING OLEFINS | PHILLIPS PETROLEUM COMPANY (US) | 1983-02-23 | — | — | EP | disclosed |
| US-4182810-A | ADDING A POLYSULFONE, POLYAMINE, AND OIL SOLUBLE SULFONIC ACID TO OLEFIN POLYMERIZATION MIXTURE | PHILLIPS PETROLEUM COMPANY (US) | 1980-01-08 | — | — | US | disclosed |
| EP-0005215-A2 | Process for polymerizing olefins | PHILLIPS PETROLEUM COMPANY (US) | 1979-11-14 | — | — | EP | disclosed |
| US-4029480-A | Hydrocarbon fuel compositions containing polysulfone antistatic additives | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-06-14 | — | — | US | disclosed |