Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.48 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 5/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL725796 | 0.76 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTHTTKDM4E | |
| SCHEMBL2970289 | 0.76 | MAPT (0.48) | ALDH1A1LMNAMAPTHTTKDM4E | |
| SCHEMBL1710671 | 0.76 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTHTTKDM4E | |
| SCHEMBL8596062 | 0.76 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTHTTKDM4E | |
| SCHEMBL10980881 | 0.76 | PARP1 (0.49) | ALDH1A1LMNAMAPTHTTKDM4E | |
| SCHEMBL3885088 | 0.74 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTHTTKDM4E | |
| SCHEMBL10587136 | 0.73 | MAPT (0.46) | ALDH1A1LMNAMAPTHTTKDM4E | |
| SCHEMBL11213799 | 0.72 | MAOA (0.41) | ALDH1A1LMNAMAPTHTTKDM4E | |
| SCHEMBL10843641 | 0.72 | MAOA (0.54) | ALDH1A1LMNAMAPTHTTKDM4E | |
| SCHEMBL8573683 | 0.72 | LIMK1 (0.50) | ALDH1A1LMNAMAPTHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0038458-B1 | 4-HYDROXY-1,2-BENZISOTHIAZOL-3(2H)-ONE-1,1-DIOXIDE, THEIR SALTS, THEIR PREPARATION AND THEIR UTILIZATION | Dr. Karl Thomae GmbH (DE) | 1983-09-21 | — | — | EP | claimed |