Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | SI | P14410 | 3/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 3/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.33 |
| ▸ | ANTXR2 | P58335 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81346 | 0.68 | ALDH1A1 (0.61) | MAOAMAOBGAAALDH1A1LMNA | |
| SCHEMBL26645428 | 0.68 | MAPT (0.53) | MAOAMAOBGAAALDH1A1LMNA | |
| SCHEMBL3887110 | 0.66 | MAOA (0.55) | MAOAMAOBMGAMGAASI | |
| SCHEMBL8833173 | 0.62 | MAOA (0.46) | MAOAMAOBMGAMGAASI | |
| SCHEMBL2588111 | 0.59 | GAA (0.42) | MGAMGAASIMGAM2ALDH1A1 | |
| Phenol SCHEMBL9065019 | 0.58 | MAPT (0.78) | MAOAMAOBALDH1A1LMNAMAPT | |
| SCHEMBL4955161 | 0.58 | ANTXR2 (0.50) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL704787 | 0.57 | ANTXR2 (0.50) | MAOAMGAMGAASIMGAM2 | |
| SCHEMBL29386163 | 0.57 | ANTXR2 (0.50) | MAOAMGAMGAASIMGAM2 | |
| SCHEMBL3884410 | 0.57 | ESR1 (0.46) | MAOAMGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0038458-B1 | 4-HYDROXY-1,2-BENZISOTHIAZOL-3(2H)-ONE-1,1-DIOXIDE, THEIR SALTS, THEIR PREPARATION AND THEIR UTILIZATION | Dr. Karl Thomae GmbH (DE) | 1983-09-21 | — | — | EP | claimed |