Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 13/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17272799 | 0.79 | KDM4E (0.45) | ALDH1A1KDM4EMAPTDDAH1LMNA | |
| SCHEMBL8596062 | 0.74 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPTDDAH1LMNA | |
| SCHEMBL11499817 | 0.71 | KDM4E (0.39) | ALDH1A1KDM4EMAPTDDAH1LMNA | |
| SCHEMBL2970289 | 0.71 | MAPT (0.48) | ALDH1A1KDM4EMAPTDDAH1LMNA | |
| SCHEMBL725796 | 0.71 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPTDDAH1LMNA | |
| SCHEMBL3290161 | 0.68 | ALOX5 (0.51) | ALDH1A1KDM4EMAPTPARP1PARP2 | |
| SCHEMBL30418394 | 0.68 | ALOX5 (0.51) | ALDH1A1KDM4EMAPTPARP1PARP2 | |
| SCHEMBL3257120 | 0.67 | MAOA (0.49) | ALDH1A1KDM4EMAPTLMNAGLA | |
| SCHEMBL7115218 | 0.67 | LIMK1 (0.50) | ALDH1A1KDM4EMAPTGLAHPGD | |
| SCHEMBL157601 | 0.66 | KDM4E (0.55) | ALDH1A1KDM4EMAPTPARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595403-B2 | Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors | ELI LILLY AND COMPANY (US) | 2009-09-29 | — | — | US | disclosed |
| US-20060276522-A1 | Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors | ELI LILLY AND COMPANY (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276522-A1 | Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors | LIPG, PNLIP, LIPC | ALDH1A1 464/4885KDM4E 3575/4885MAPT 4397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.