Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18805037 | 1.00 | BRD4 (0.48) | BRD4DRD2SLC6A4CHRNB2CHRNA4 | |
| SCHEMBL12209283 | 0.84 | GRM4 (0.49) | BRD4CHRNB2CHRNA4HTR3AGRM4 | |
| SCHEMBL30716972 | 0.84 | GRM4 (0.49) | BRD4CHRNB2CHRNA4HTR3AGRM4 | |
| SCHEMBL30106863 | 0.83 | BRD4 (0.42) | BRD4DRD2SLC6A4CHRNB2CHRNA4 | |
| SCHEMBL4399692 | 0.79 | CHRNB2 (0.45) | BRD4CHRNB2CHRNA4CHRNA7HTR3A | |
| SCHEMBL20393972 | 0.78 | ACHE (0.42) | DRD2SLC6A4ACHECHRNA7HTR3A | |
| SCHEMBL10222158 | 0.76 | ALDH1A1 (0.49) | BRD4CHRNB2CHRNA4CHRNA7HTR3A | |
| SCHEMBL4098321 | 0.76 | ALDH1A1 (0.44) | BRD4CHRNB2CHRNA4ACHEGRM4 | |
| SCHEMBL745847 | 0.76 | ESR1 (0.62) | ESR1ESR2 | |
| SCHEMBL18788867 | 0.76 | CHRNB2 (0.42) | BRD4CHRNB2CHRNA4GRM4ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117304205-A | Benzimidazole ternary fused ring compound, pharmaceutically acceptable salt thereof and application thereof | 中国科学院广州生物医药与健康研究院 | 2023-12-29 | — | — | CN | disclosed |
| EP-3192792-B1 | AMINOSULFONYL-BASED COMPOUNDS, PREPARATION METHOD THEREFOR AND USE THEREOF | SUZHOU VIGONVITA LIFE SCIENCES CO LTD (CN) | 2022-03-09 | — | — | EP | disclosed |
| CN-109574945-B | Isoxazoline derivatives and their use in agriculture | 东莞市东阳光农药研发有限公司 | 2021-04-20 | — | — | CN | disclosed |
| EP-3733670-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | Mediconns (Shanghai) Biopharmaceutical Co., Ltd (CN) | 2020-11-04 | — | — | EP | disclosed |
| WO-2020156312-A1 | POLYCYCLIC DERIVATIVE MODULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 江苏豪森药业集团有限公司 | 2020-08-06 | — | — | WO | disclosed |
| US-10259800-B2 | Method of fluorination using iodonium ylides | THE GENERAL HOSPITAL CORPORATION (US) | 2019-04-16 | — | — | US | disclosed |
| US-10259800-B2 | Method of fluorination using iodonium ylides | THE GENERAL HOSPITAL CORPORATION (US) | 2019-04-16 | — | — | US | disclosed |
| US-10093679-B2 | Amino sulfonyl-based compounds, the preparation method therefor and use thereof | SUZHOU VIGONVITA LIFE SCIENCES CO., LTD (CN) | 2018-10-09 | — | — | US | disclosed |
| US-20170298080-A1 | AMINOSULFONYL COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-10-19 | — | — | US | disclosed |
| US-20170298080-A1 | AMINOSULFONYL COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-10-19 | — | — | US | disclosed |
| US-6355796-B1 | REACTING BETA-AMINO-BETA-(PERFLUOROALKYL)ACRYLATE COMPOUND WITH BASE AND CARBAMOYL CHLORIDE COMPOUND TO FORM UREA COMPOUND, REACTING UREA COMPOUND WITH PHOSPHORUS PENTAHALIDE OR OXALYL HALIDE | BASF AKTIENGESELLSCHAFT (DE) | 2002-03-12 | — | — | US | disclosed |
| EP-1171427-A1 | PROCESS FOR THE PREPARATION OF 6-(PERFLUOROALKYL) URACIL COMPOUNDS FROM UREA COMPOUNDS | AMERICAN CYANAMID COMPANY (US) | 2002-01-16 | — | — | EP | disclosed |
| EP-1150962-A1 | PROCESS FOR THE PREPARATION OF 6-(PERFLUOROALKYL)URACIL COMPOUNDS FROM CARBAMATE COMPOUNDS | AMERICAN CYANAMID COMPANY (US) | 2001-11-07 | — | — | EP | disclosed |
| US-6313295-B1 | REACTING CARBAMATE WITH AMINE; CYCLIZATION, ALKYLATION | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-06 | — | — | US | disclosed |
| US-6191275-B1 | REACTING ETHYL 3-((N,N-DIMETHYLCARBAMOYL)AMINO)-4,4,4-TRIFLUOROCROTONATE, FOR EXAMPLE WITH AMINO COMPOUNDS IN ACID OR BASE TO FORM HERBICIDES OF FORMULA 1-(OPTIONALLY ALKYL), 3-(SUBSTITUTED),6-(PERFLUOROALKYL)-1H,4H-PYRIMIDINE-2,4-DIONE | AMERICAN CYANAMID COMPANY | 2001-02-20 | — | — | US | disclosed |
| US-6156700-A | 3-(1,2-Benzisothiazol- and isoxazol-5-yl)-2,4(1H,3H)-pyrimidinedione or thione and 3-(1,2-benzisothiazol- and isoxazol-5-yl)-4(3H)-pyrimidinone or thione herbicidal agents | AMERICAN CYANMID COMPANY (US) | 2000-12-05 | — | — | US | disclosed |
| US-6140270-A | BY REACTING THEM WITH AN AMINE COMPOUND AND AN ACID OR BASE; HERBICIDES | AMERICAN CYANAMID COMPANY | 2000-10-31 | — | — | US | disclosed |
| WO-2000049003-A1 | PROCESS FOR THE PREPARATION OF 6-(PERFLUOROALKYL)URACIL COMPOUNDS FROM CARBAMATE COMPOUNDS | AMERICAN CYANAMID COMPANY (US) | 2000-08-24 | — | — | WO | disclosed |
| WO-2000049004-A1 | PROCESS FOR THE PREPARATION OF 6-(PERFLUOROALKYL) URACIL COMPOUNDS FROM UREA COMPOUNDS | AMERICAN CYANAMID COMPANY (US) | 2000-08-24 | — | — | WO | disclosed |
| EP-0908457-A1 | 3-(1,2-benzisothiazol- and isoxazol-5-Y1)-2,4(1H,3H)-pyrimidinedione or thione and 3-(1,2-benzisothiazol- and isoxazol-5-y1)-4(3H)-pyrimidinone or thione herbicidal agents | American Cyanamid Company (US) | 1999-04-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10093679-B2 | Amino sulfonyl-based compounds, the preparation method therefor and use thereof | SLC6A11, HADHB, NOTUM | BRD4 3665/4885DRD2 3984/4885SLC6A4 256/4885 |
| US-20170298080-A1 | AMINOSULFONYL COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | NOTUM, ALDH7A1, HADHB | BRD4 3079/4885DRD2 4432/4885SLC6A4 657/4885 |
| US-10259800-B2 | Method of fluorination using iodonium ylides | FLI1, ABL1, PFAS | BRD4 177/4885DRD2 2124/4885SLC6A4 942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.