Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tetrabuthylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 3/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.41 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrabuthylammonium SCHEMBL5874524 | 0.98 | SLC22A1 (0.55) | SLC22A1GPR84FFAR1SLC22A2TSHR | |
| Tetrabuthylammonium SCHEMBL5874528 | 0.90 | SLC22A1 (0.46) | SLC22A1GPR84FFAR1SLC22A2TSHR | |
| Cadaverine Tartrate SCHEMBL15561036 | 0.88 | SLC22A1 (0.52) | SLC22A1GPR84FFAR1SLC22A2TSHR | |
| Tetrabuthylammonium SCHEMBL27706863 | 0.87 | SLC22A1 (0.52) | SLC22A1GPR84FFAR1SLC22A2TSHR | |
| Cadaverine Tartrate SCHEMBL27745708 | 0.86 | TSHR (0.59) | GPR84FFAR1TSHRALDH1A1ALOX15 | |
| Tetrabuthylammonium SCHEMBL331982 | 0.84 | SLC22A1 (0.55) | SLC22A1GPR84FFAR1SLC22A2TSHR | |
| Tetrapropylammonium SCHEMBL5874099 | 0.84 | TSHR (0.50) | SLC22A1GPR84FFAR1TSHRTP53 | |
| Cadaverine Tartrate SCHEMBL8550409 | 0.84 | GPR84 (0.62) | GPR84FFAR1TSHRALDH1A1ALOX15 | |
| Cadaverine Tartrate SCHEMBL8331400 | 0.84 | GPR84 (0.62) | GPR84FFAR1TSHRALDH1A1ALOX15 | |
| Cadaverine Tartrate SCHEMBL27345329 | 0.84 | GPR84 (0.62) | GPR84FFAR1TSHRALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4313843-A | CHEMILUMINESCENT HAVING GOOD STORAGE STABILITY | AMERICAN CYANAMID COMPANY (US) | 1982-02-02 | — | — | US | disclosed |